Transcriptomic and Metabolomic Analyses of Palaemon carinicauda Hepatopancreas in Response to Enterocytozoon hepatopenaei (EHP) Infection

Enterocytozoon hepatopenaei (EHP), a microsporidian responsible for hepatopancreatic microsporidiosis, is major pathogen in commercial shrimp production. Among the affected species, Palaemon carinicauda (formerly Exopalaemon carinicauda) commercially important China and represents potential research model studying crustaceans. However, little information available on its response to EHP infection. Hence, this study analyzed transcriptome metabolome of P. carinicauda’s hepatopancreas using high-throughput sequencing liquid chromatograph-mass spectrometry (LC-MS) determine during early stage The transcriptomic analyses identified 730 differentially expressed genes, which those associated with infection were enriched metabolic pathways as well detoxification antioxidant pathways. In addition, 144 differential metabolites combination positive negative ion modes LC-MS. Kyoto encyclopedia genes genomes pathway further indicated that degradation aromatic compounds, AMP-activated protein kinase signaling C5-branched dibasic acid metabolism significantly after These results could provide useful insights into effects shrimps stages help understand mechanisms underlying stunted growth